OBJECTIVE: To report 6 cases of severe local reactions associated with intramuscular injection of diclofenac. CONCLUSIONS: Intramuscular administration of diclofenac may be associated with severe tissue necrosis or necrotizing fasciitis. thighs after intramuscular injection of metoclopramide. We discuss and highlight . neous tissue, necrosis of perforating vessels, and purulent and malodorous.